Nine of the 16 seeds have already been eliminated from this competition, but Trump has been in superb form as he has swept into the last eight for a 10th time.
On Friday Trump held a 6-2 advantage and extended that to 9-3, before ending the second session with an 11-5 lead, only needing two more frames for victory.
A break of 76 helped Ford win the opening frame of Saturday, before Trump moved to the brink with an excellent break of 107 – the 979th century of his career.
He missed out on his 980th shortly afterwards, but the break of 79 was enough to clinch the vistory.
Elsewhere, Scotland’s Stephen Maguire held a 5-3 advantage over England’s 2005 world champion Shaun Murphy and the pair shared the opening two frames on table one.
The last-16 matches are the best of 25, so the first to 13.
Later on, Northern Ireland’s Mark Allen, who could end the tournament as world number one, takes on Scotland’s four-time champion John Higgins in what promises to be one of the matches of the competition so far.
The evening session at 19:00 features the start of two last-16 matches as Joe O’Connor, winner over four-time champion Mark Selby in round one, takes on Kyren Wilson.
Stuart Bingham, a Crucible winner in 2015, faces fellow Englishman Jack Lisowski.
