In Human Esophageal Epithelial and Muscle Cells Treated With T-Helper Type 2 Cytokines, Upadacitinib Decreases Eotaxin-3 Secretion and Muscle Tension
In eosinophilic esophagitis (EoE), food and other allergens induce a type 2 inflammatory response in which T helper type 2 (Th2) cells secrete interleukin (IL) 4 and IL13, cytokines that signal through the type II IL4 receptor to activate janus kinase (JAK).1,2 In esophageal epithelial and esophageal smooth muscle (ESM) cells, activated JAK phosphorylates signal transducer and activator of transcription 6 (STAT6), which translocates to the nucleus to initiate transcription of eotaxin-3, a chemoattractant that draws eosinophils into the EoE esophagus.
