Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma
Lysyl oxidase expression is enhanced in cholangiocarcinoma tumors and predictive of poor survival. Lysyl oxidase is found mainly in cancer-associated fibroblasts, resident stromal cells responsible for shaping the tumor microenvironment. Lysyl oxidase inactivation in vivo shows diminished cholangiocarcinoma burden in murine livers. Therefore, targeting lysyl oxidase may be a promising therapeutic strategy in cholangiocarcinoma.
