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Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs
Our study demonstrates that simultaneous inhibition of CDK4/6 and XPO1 induces senescence in liver cancer cells, making them susceptible to CRBN-based PROTAC drugs.
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