Is the Molecular Classification of ERBB2 in Stage III Colon Cancer Clinically Ready?



The study by Pilati et al1 presents a comprehensive molecular characterization of ERBB2 in stage III colon cancer, proposing a novel classification integrating RNA and DNA analyses. Although this work advances our understanding of ERBB2 heterogeneity, several critical limitations in methodology and interpretation require urgent attention to ensure clinical translatability.

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